A 49-year-old male presents with Peyronie's disease. Which physical examination finding is most likely?

• A. Inflammation of the glands of the penis
• B. Foreskin that cannot be retractated
• C. Chancre on the shaft of the penis
• D. Fibrous band on the lateral aspect of the penis

Answer: (D)

Peyronie’s disease involves scar tissue forming in the tunica albuginea of the penis, leading to penile curvature and sometimes painful erections. On physical exam, this points to a firm, non-tender fibrous plaque or band that can be felt along the shaft, often on the dorsal or lateral aspect. This palpable fibrous band is the classic finding you’d expect with Peyronie’s.

The other options describe conditions that don’t fit Peyronie’s: inflammation of the penile glands would be balanitis; a nonretractable foreskin indicates phimosis; a chancre on the shaft suggests primary syphilis. The fibrous band is the finding that matches Peyronie’s pathology.