In a patient with hypertension on thiazide diuretics, EKG shows U waves. Which electrolyte abnormality is most likely?

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Multiple Choice

In a patient with hypertension on thiazide diuretics, EKG shows U waves. Which electrolyte abnormality is most likely?

Explanation:
U waves on an EKG are most strongly associated with hypokalemia. Thiazide diuretics promote potassium loss by inhibiting NaCl reabsorption in the distal tubule, which increases delivery of sodium to the collecting duct and drives potassium secretion there. The resulting lower potassium level often manifests as U waves, along with other ECG changes like flattened T waves and ST changes, and it can predispose to arrhythmias. Other options don’t fit as neatly: beta-blocker effects alter heart rate/conduction but don’t cause U waves; hypocalcemia tends to prolong the QT interval rather than produce U waves; nonadherence could lead to varied issues but isn’t the classic cause of U waves.

U waves on an EKG are most strongly associated with hypokalemia. Thiazide diuretics promote potassium loss by inhibiting NaCl reabsorption in the distal tubule, which increases delivery of sodium to the collecting duct and drives potassium secretion there. The resulting lower potassium level often manifests as U waves, along with other ECG changes like flattened T waves and ST changes, and it can predispose to arrhythmias. Other options don’t fit as neatly: beta-blocker effects alter heart rate/conduction but don’t cause U waves; hypocalcemia tends to prolong the QT interval rather than produce U waves; nonadherence could lead to varied issues but isn’t the classic cause of U waves.

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