In bacterial vaginosis, which finding on a wet mount is characteristic?

• A. Yeast buds.
• B. Clue cells.
• C. Motile flagellates.
• D. Epithelial inclusion bodies.

Answer: (A)

Clue cells on a saline wet mount are characteristic of bacterial vaginosis. These are vaginal epithelial cells whose borders are obscured and appear stippled because bacteria adhere to their surfaces, giving the cells a granular, smudged look. This pattern reflects disruption of the normal lactobacilli-dominated flora and overgrowth of anaerobic bacteria such as Gardnerella. It helps distinguish BV from candida infection, where budding yeast are seen; from Trichomonas infection, where motile protozoa are present; and from findings that aren’t typical of BV like epithelial inclusion bodies. Recognizing clue cells supports the BV diagnosis and helps guide treatment.