In myxedema, which symptom is most commonly reported?

• A. tremors
• B. palpitations
• C. cold intolerance
• D. eructation

Answer: (C)

Myxedema represents severe hypothyroidism, where the metabolic rate is markedly reduced. With less thyroid hormone, tissues generate less heat, so patients commonly feel cold and seek extra warmth—this cold intolerance is a hallmark symptom. Tremors and palpitations are more typical of hyperthyroidism, where there is increased sympathetic activity and heat production. Eructation is not a characteristic feature of thyroid disease. Thus, cold intolerance is the symptom most commonly reported in myxedema.