Renal cell carcinoma commonly presents with which sign?

• A. Hypercalcemia
• B. Inguinal pain
• C. Hematuria
• D. Weight loss

Answer: (C)

Renal cell carcinoma classically presents with blood in the urine because the tumor frequently invades the renal tissue and collecting system, leading to hematuria that can be gross or microscopic. This sign is the most characteristic when symptoms are present, even though many RCC cases are found incidentally on imaging and may not have noticeable symptoms. While other features like hypercalcemia can occur as a paraneoplastic effect and weight loss can accompany advanced disease, these are less specific and not as common as hematuria. Inguinal pain is not a typical feature of RCC. Therefore, hematuria best fits the common clinical presentation of this cancer.