The treatment of choice for uncomplicated gonococcal urethritis is

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Multiple Choice

The treatment of choice for uncomplicated gonococcal urethritis is

Explanation:
The main idea is choosing an antibiotic with reliable activity against Neisseria gonorrhoeae despite widespread resistance to older drugs. Gonorrhea has become resistant to penicillin, and also to drugs like trimethoprim-sulfamethoxazole and metronidazole, so those are not effective choices for this infection. Ceftriaxone, a third-generation cephalosporin given intramuscularly, remains highly effective against gonococcus and provides good mucosal and tissue penetration, making it the treatment of choice for uncomplicated gonococcal urethritis. In practice, clinicians often consider dual therapy to cover possible Chlamydia coinfection, but ceftriaxone is the backbone of therapy due to its proven efficacy against Neisseria gonorrhoeae.

The main idea is choosing an antibiotic with reliable activity against Neisseria gonorrhoeae despite widespread resistance to older drugs. Gonorrhea has become resistant to penicillin, and also to drugs like trimethoprim-sulfamethoxazole and metronidazole, so those are not effective choices for this infection. Ceftriaxone, a third-generation cephalosporin given intramuscularly, remains highly effective against gonococcus and provides good mucosal and tissue penetration, making it the treatment of choice for uncomplicated gonococcal urethritis. In practice, clinicians often consider dual therapy to cover possible Chlamydia coinfection, but ceftriaxone is the backbone of therapy due to its proven efficacy against Neisseria gonorrhoeae.

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